| Dopaminergic pathway | Significance | Action of drug blocking D2 receptors |
| Nigrostriatal | Movement | Extrapyramidal symptoms |
| Mesolimbic | Speech, grasp of reality, mentation, and mood | Reduces positive symptoms of schizophrenia |
| Mesocortical | Motivation, pleasure, socialization | May increase negative symptoms of schizophrenia |
| Tuberoinfundibular pathway | Inhibits prolactin release | Hyperprolactinemia |
| Chemoreceptor trigger zone | Vomiting reflex | Anti emetic |
💎 PearlMarrowPsychiatryPM2418
Actions of Antipsychotic Drugs
Pm2418. Actions of Antipsychotic Drugs