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💎 PearlMarrowPharmacologyPM2484

Mechanism of Action of Common Anti-Epileptics

Pm2484. Mechanism of Action of Common Anti-Epileptics

Mechanism of action of some common antiepileptics:
Mechanism of action Antiepileptics
Sodium channel blockers
  • Phenytoin
  • Carbamazepine
  • Oxcarbazepine
  • Eslicarbazepine
  • Lamotrigine
  • Topiramate
  • Felbamate
  • Valproate
  • Rufinamide
Calcium-channel blockers
  • Valproate
  • Lamotrigine
  • Ethosuximide
GABAA receptor modulators
  • Benzodiazepine
  • Phenobarbital
  • Felbamate
  • Primidone
  • Topiramate
  • Carbamazepine
  • Oxcarbazepine
  • Stiripentol
  • Clobazam
GABA uptake inhibitors
  • Tiagabine
  • Vigabatrin
Synaptic vesicle glycoprotein 2A(SV2A) inhibitors
  • Levetiracetam
  • Brivaracetam
NMDA receptor antagonist
  • Felbamate
AMPA/Kainate receptor antagonist
  • Phenobarbital
  • Topiramate
  • Perampanel
HCN channel activity enhancers
  • Lamotrigine
Inhibitors of brain carbonic anhydrase
  • Acetazolamide
  • Zonisamide
  • Topiramate
Potassium-channel openers
  • Retigabine
  • Topiramate